European medical agencies recommend mixing Covid vaccines

WHO gives seal of approval to combining COVID vaccines

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European medical agencies recommend mixing Covid vaccines

On Tuesday, December 7, the European Medicines Agency (EMA), along with the European Centre for Disease Control (ECDC), indicated that they believe a combination of two different Covid vaccines offers a “reinforced” immune response.

They have thus recommended this strategy – known as heterologous vaccination – to national vaccination authorities. It suggested that as far as possible, this approach could be used in both the primary and booster phases. This hybrid methodology, they emphasised, could give “greater flexibility” to national vaccination campaigns.

In a joint statement, the two European agencies said, “Currently available evidence consistently points towards acceptable tolerance, and enhanced immune response with the heterologous regimen of a vector-based vaccine and another on messenger RNA versus a homologous regimen”.

Member states were also encouraged to strengthen their campaigns for the complete immunisation of the European population. Although some studies suggest that it could produce greater side effects, such as fatigue, fever, and headache, these results “are not consistent”, nor is there evidence of possible adverse reactions, they added.

The EMA and ECDC explained that in light of recent studies, there is “consistent evidence” that the heterologous regimen reduces gaps in the immune response. It also offers greater reactivity against “worrisome variants” of Covid-19, which would explain the “improved efficacy” revealed by studies conducted to date.

This new European recommendation addresses both the initial vaccination regimen, and the administration of the booster. More research is still needed, however, to study mixed vaccine programs for immunosuppressed people they pointed out.

European authorisation comes after a study released on Monday 6, claimed that the first dose of AstraZeneca, or Pfizer-BioNTech vaccines, followed by a Moderna vaccine nine weeks later, produced a better immune response.

Spain, the United Kingdom, and other countries, have already adopted this approach during the first phase of the vaccination campaign, in part to overcome supply problems. But, the European recommendation is relevant for the administration of booster doses.

The United States has already given the green light to the vaccine combination, and the World Health Organization is evaluating it, as reported by


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Written by

Chris King

Originally from Wales, Chris spent years on the Costa del Sol before moving to the Algarve where he is a web reporter for The Euro Weekly News covering international and Spanish national news. Got a news story you want to share? Then get in touch at