AstraZeneca Begins Trials Of ‘Tweaked’ Booster Vaccine Against Covid-19 Variant

Image: AstraZeneca Media

AstraZeneca Begins Trials Of ‘Tweaked’ Booster Vaccine Against Covid-19 Variant.

AstraZeneca and the University of Oxford on Sunday (June 27) began new trials to test a modified ‘tweaked’ version of their vaccine against the Covid-19 Beta variant, which first emerged in South Africa.

This Variant of Concern emerged last year and is still in the UK at low levels. It is also less susceptible to the vaccines than other strains, scientists believe. It was previously tested in a lab and on mice and the researchers said: “AZD2816 is immunogenic (substance able to produce an immune response) after a single dose and when used as a booster dose in animals primed with [the] original vaccine.”

These variants are called variants of concern (VOCs), the best-known being B.1.1.7 (Alpha), first identified in the UK; B.1.351 (Beta), in South Africa; and P.1 (Gamma), in Brazil, besides the most recently reported variants, B.1.617.1 (Kappa) and B.1.617.2 (Delta).

The “booster” vaccine’s trial is set to involve around 2,250 participants from across Britain, South Africa, Brazil and Poland.

The trial participants include people who have already been fully vaccinated with two doses of the original Oxford-AstraZeneca vaccine or an mRNA vaccine such as Pfizer’s, as well as those who have not got the jab at all.

The new vaccine, known as AZD2816, has been designed using the same base as the main AstraZeneca shot but with minor genetic alterations to the spike protein based on the Beta variant.

“Testing booster doses of existing vaccines and new variant vaccines is important to ensure we are best prepared to stay ahead of the pandemic, should their use be needed,” said Mr Andrew Pollard, chief investigator and director of the Oxford Vaccine Group at the University of Oxford.

Britain has had a successful vaccine roll-out programme, but experts do not know how long the protection lasts.

Almost 44 million people in the UK have received at least one dose of a coronavirus vaccine – part of the biggest inoculation programme the country has ever launched.

With the aim of offering vaccines to all adults by mid-July, the government says the continued success of the vaccine programme is crucial to further easing of restrictions.


Thank you for taking the time to read this article, please remember to come back and check The Euro Weekly News website for all your up-to-date local and international news stories.

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Ron Howells

Ron actually started his working career as an Ophthalmic Technician- things changed when, during a band rehearsal, his amplifier blew up and he couldn’t get it fixed so he took a course at Birmingham University and ended up doing a degree course. He built up a chain of electronics stores and sold them as a franchise over 35 years ago. After five years touring the world Ron decided to move to Spain with his wife and son, a place they had visited over the years, and only bought the villa they live in because it has a guitar-shaped swimming pool!. Playing the guitar since the age of 7, he can often be seen, (and heard!) at beach bars and clubs along the length of the coast. He has always been interested in the news and constantly thrives to present his articles in an interesting and engaging way.


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